How mitochondrial donation therapy works
1
Mother’s
fertilised egg
Mutated
mitochondrion
Nucleus
Parents’ nucleus
material removed and kept
2
Donor’s
fertilised egg
Healthy
mitochondrion
Donor nucleus material
removed and discarded
3
Fertilised egg for
transplantation
into mother
Parents’ nucleus material
placed inside donor egg
1
Mother’s
fertilised egg
Mutated
mitochondrion
Nucleus
Parents’ nuclear
material removed and kept
2
Donor’s
fertilised egg
Healthy
mitochondrion
Donor nuclear material
removed and discarded
3
Fertilised egg for
transplantation
into mother
Parents’ nuclear material
placed inside donor egg
1 Mother’s
fertilised egg
2 Donor’s
fertilised egg
3 Fertilised egg for
transplantation
into mother
Mutated
mitochondrion
Healthy
mitochondrion
Nucleus
Parents’ nuclear
material removed
and kept
Donor nuclear
material removed
and discarded
Parents’ nuclear
material placed
inside donor egg
1 Mother’s
fertilised egg
2 Donor’s
fertilised egg
3 Fertilised egg for
transplantation into mother
Mutated
mitochondrion
Healthy
mitochondrion
Nucleus
Parents’ nuclear material
removed and kept
Donor nuclear material
removed and discarded
Parents’ nuclear material
placed inside donor egg
1
Mother’s
fertilised egg
Mutated
mitochondrion
Nucleus
Parents’ nucleus
material removed and kept
2
Donor’s
fertilised egg
Healthy
mitochondrion
Donor nucleus material
removed and discarded
3
Fertilised egg for
transplantation
into mother
Parents’ nucleus material
placed inside donor egg
1
Mother’s
fertilised egg
Mutated
mitochondrion
Nucleus
Parents’ nuclear
material removed and kept
2
Donor’s
fertilised egg
Healthy
mitochondrion
Donor nuclear material
removed and discarded
3
Fertilised egg for
transplantation
into mother
Parents’ nuclear material
placed inside donor egg
1 Mother’s
fertilised egg
2 Donor’s
fertilised egg
3 Fertilised egg for
transplantation
into mother
Mutated
mitochondrion
Healthy
mitochondrion
Nucleus
Parents’ nuclear
material removed
and kept
Donor nuclear
material removed
and discarded
Parents’ nuclear
material placed
inside donor egg
1 Mother’s
fertilised egg
2 Donor’s
fertilised egg
3 Fertilised egg for
transplantation into mother
Mutated
mitochondrion
Healthy
mitochondrion
Nucleus
Parents’ nuclear material
removed and kept
Donor nuclear material
removed and discarded
Parents’ nuclear material
placed inside donor egg