| Rk | Player | Date | Points |
|---|---|---|---|
| 1 | Wilt Chamberlain, Phila Warriors | 2 Mar 1962 | 100 |
| 2 | Kobe Bryant, LA Lakers | 22 Jan 2006 | 81 |
| 3 | Wilt Chamberlain, Phila Warriors | 8 Dec 1961 | 78 |
| 4 | Wilt Chamberlain, Phila Warriors | 13 Jan 1962 | 73 |
| Wilt Chamberlain, SF Warriors | 16 Nov 1962 | 73 | |
| David Thompson, Nuggets | 9 Apr 1978 | 73 | |
| 7 | Wilt Chamberlain, SF Warriors | 3 Nov 1962 | 72 |
| 8 | Elgin Baylor, LA Lakers | 15 Nov 1960 | 71 |
| David Robinson, Spurs | 24 Apr 1994 | 71 | |
| Donovan Mitchell, Cavaliers | 2 Jan 2023 | 71 | |
| Damian Lillard, Trail Blazers | 26 Feb 2023 | 71 | |
| 12 | Wilt Chamberlain, SF Warriors | 10 Mar 1963 | 70 |
| Devin Booker, Suns | 24 Mar 2017 | 70 | |
| Joel Embiid, Sixers | 22 Jan 2024 | 70 |
Guardian graphic. Source: NBA.