T-cell cancer therapy: how engineered immune cells can kill tumours

1

Blood is drawn from the patient and the T-cells are separated out

T-cells

normally kill

pathogen-

infected

cells

2

The T-cells are genetically engineered to produce surface receptors called CARs

 

Engineered

T-cell with

receptors

3

These receptors allow T-cells to recognise and attach to a specific protein on tumour cells

Cancerous

cell

4

The CAR T-cells multiply in the lab and are then sent back to the patient

5

Transfused back into the body, the CAR T-cells recognise and kill cancerous cells

Modified

T-cell

infusion

1

Blood is drawn from the patient and the T-cells are separated out

2

The T-cells are genetically engineered to produce surface receptors called CARs

3

These receptors allow T-cells to recognise and attach to a specific protein on tumour cells

Blood

drawn

T-cells normally

kill pathogen-

infected cells

Engineered T-cell

with receptors

Cancerous

cell

Modified

T-cell

infusion

Hundreds of

millions produced

5

Transfused back into the body, the CAR T-cells recognise and kill cancerous cells

4

The CAR T-cells multiply in the lab and are then sent back to the patient