How injecting materials designed to encourage tissue repair could help recovery from a spinal cord injury

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Mouse with a spinal

cord injury

Designer molecules

introduced

Dissolved nanofibres are injected at the site of injury - the liquid turns into a gel as soon as it comes into contact with the tissue

The nanofibres are able to move back and forth allowing them to make contact with neurons at the injury site

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4

Matrix forms at the

injury site

Partial repair to

spinal cord

Signalling between the nanofibres and the surrounding tissue triggers the regeneration of neurons and promotes the growth of blood vessels that helps encourage tissue repair

Within three to four weeks there are visible changes to the tissue and the mice regain the ability to walk. Within 12 weeks the injected nanofibres have biodegraded and then completely disappear from the body

Mouse with a spinal

cord injury

Designer molecules

introduced

Matrix forms at the

injury site

Partial repair to

spinal cord

Dissolved nanofibres are injected at the site of injury - the liquid turns into a gel as soon as it comes into contact with the tissue

The nanofibres are able to move back and forth allowing them to make contact with neurons at the injury site

Signalling between the nanofibres and the surrounding tissue triggers the regeneration of neurons and promotes the growth of blood vessels that helps encourage tissue repair

Within three to four weeks there are visible changes to the tissue and the mice regain the ability to walk. Within 12 weeks the injected nanofibres have biodegraded and then completely disappear from the body