Depression is often currently treated with selective serotonin reuptake inhibitors (SSRIs) ...

1

Serotonin – a messenger chemical also thought to influence mood – carries its signal from one neuron to the next

Serotonin

1

Release site

Receptor site

Synapse

Post-synaptic

nerve ending

Pre-synaptic

nerve ending

2

SSRIs

2

SSRIs block reabsorption sites, raising serotonin levels in the synapse and increasing its effect

... a new ketamine infusion therapy nasal spray can help treat patients much faster

3

Ketamine – an anaesthetic and analgesic – allows serotonin and other chemicals to work normally and does not block reabsorption sites

Serotonin

and other

chemicals

Reabsorption site

Receptor site

3

4

4

Instead it is thought to stimulate the development of new receptors of various types and so increase the effectiveness of signalling between neurons

Depression is often currently treated with selective serotonin reuptake inhibitors (SSRIs) ...

... a new ketamine infusion therapy nasal spray can help treat patients much faster

1

3

Serotonin – a messenger chemical also thought to influence mood – carries its signal from one neuron to the next

Ketamine – an anaesthetic and analgesic – allows serotonin and other chemicals to work normally and does not block reabsorption sites

Serotonin

Serotonin

and other

chemicals

1

Release site

Synapse

Receptor site

Reabsorption site

Receptor site

3

4

Post-synaptic

nerve ending

Pre-synaptic

nerve ending

2

SSRIs

2

4

SSRIs block reabsorption sites, raising serotonin levels in the synapse and increasing its effect

Instead it is thought to stimulate the development of new receptors of various types and so increase the effectiveness of signalling between neurons