How gene editing could lower the risk of heart attack

1

Patient has an injection in their arm containing ‘nanolipids’. The nanolipids are tiny, fatty spheres designed to home in on liver cells

Heart

Liver

2

Nanolipids infiltrate liver cells and release a gene editing tool called Crispr-Cas9

Nanolipid

Crispr-Cas9

Liver

cell

Nucleus

3

Crispr-Cas9 locates a gene called PCSK9 and turns it off. Silencing 30-40% of PCSK9 should protect against heart attack

Silenced

gene

1

2

Patient has an injection in their arm containing ‘nanolipids’. The nanolipids are tiny, fatty spheres designed to home in on liver cells

Nanolipids infiltrate liver cells and release a gene editing tool called Crispr-Cas9

Nanolipid

Heart

Crispr-

Cas9

Liver

cell

Liver

Nucleus

Chromosome

in nucleus

Silenced

gene

3

Crispr-Cas9 locates a gene called PCSK9 and turns it off. Silencing 30-40% of PCSK9 should protect against heart attack