1
Patient has an injection in their arm containing ‘nanolipids’. The nanolipids are tiny, fatty spheres designed to home in on liver cells
Heart
Liver
2
Nanolipids infiltrate liver cells and release a gene editing tool called Crispr-Cas9
Nanolipid
Crispr-Cas9
Liver
cell
Nucleus
3
Crispr-Cas9 locates a gene called PCSK9 and turns it off. Silencing 30-40% of PCSK9 should protect against heart attack
Silenced
gene
1
2
Patient has an injection in their arm containing ‘nanolipids’. The nanolipids are tiny, fatty spheres designed to home in on liver cells
Nanolipids infiltrate liver cells and release a gene editing tool called Crispr-Cas9
Nanolipid
Heart
Crispr-
Cas9
Liver
cell
Liver
Nucleus
Chromosome
in nucleus
Silenced
gene
3
Crispr-Cas9 locates a gene called PCSK9 and turns it off. Silencing 30-40% of PCSK9 should protect against heart attack