1
An RNA ‘guide’ molecule can be programmed to match any unique DNA sequence
2
The RNA molecule is attached to a protein called CAS9. Its job is to find the target sequence of DNA
Cas9
RNA
molecule
DNA target sequence
DNA sequence
3
The RNA aligns with the target DNA sequence and the CAS9 attaches and cuts both strands of the DNA double helix, disabling the gene
Cas9
RNA aligns
with DNA
sequence
1
An RNA ‘guide’ molecule can be programmed to match any unique DNA sequence
Cas9
RNA
molecule
2
The RNA molecule is attached to a protein called CAS9. Its job is to find the target sequence of DNA
DNA target sequence
DNA sequence
3
The RNA aligns with the target DNA sequence and the CAS9 attaches and cuts both strands of the DNA double helix, disabling the gene
Cas9
RNA
molecule
RNA aligns with DNA sequence