How nanotechnology could be used to rapidly rewarm cryogenically treated organs without damaging frozen tissues

1

Donor organ is harvested and is organ is perfused with cryoprotectant solution and iron oxide nanoparticles

 

 

Cryoprotectant

solution

Iron oxide nanoparticles

2

Organ is cooled to -160C, ready for storage in liquid nitrogen in an organ cryo-bank. The cryoprotectant means the organ is turned into a vitrified (glassy) state without damaging ice crystals forming

 

Ice crystals are

prevented from

forming

3

When the donor organ is required, it is placed in an induction coil, which generates a magnetic field whose direction can be rapidly alternated. This causes the magnetic nanoparticles to jiggle and generate warming evenly throughout the organ

Magnetic field

Organ reaches thawing

point within about a minute

Organ can

reach

thawing

point within

about a

minute

Cryoprotectant

solution

Ice crystals are prevented

from forming

Magnetic field

Iron oxide

nanoparticles

1

Donor organ is harvested and is organ is perfused with cryoprotectant solution and iron oxide nanoparticles

 

 

2

Organ is cooled to -160C, ready for storage in liquid nitrogen in an organ cryo-bank. The cryoprotectant means the organ is turned into a vitrified (glassy) state without damaging ice crystals forming

 

3

When the donor organ is required, it is placed in an induction coil, which generates a magnetic field whose direction can be rapidly alternated. This causes the magnetic nanoparticles to jiggle and generate warming evenly throughout the organ