Guardian graphic

BACE1

inhibitor

prevents

plaques

forming

Neuron

Sticky

plaques

Amyloid

beta

peptides

Signal

disrupted

2

The BACE1 inhibitor enters the brain and ‘switches off’ the enzyme's production, helping to prevent new plaques forming

How BACE1 blocking drug could reduce toxic proteins in Alzheimer's patients

1

In Alzheimer's, BACE1 snips longer proteins into smaller amyloid beta chunks, which go on to form sticky plaques

The plaques form outside of the brain's neurons, disrupting signals and compromising brain function

Guardian graphic

BACE1

inhibitor

prevents

plaques

forming

Neuron

Sticky

plaques

Amyloid

beta

peptides

Signal

disrupted

2

The BACE1 inhibitor enters the brain and ‘switches off’ the enzyme's production, helping to prevent new plaques forming

1

In Alzheimer's, BACE1 snips longer proteins into smaller amyloid beta chunks, which go on to form sticky plaques

The plaques form outside of the brain's neurons, disrupting signals and compromising brain function

How BACE1 blocking drug could reduce toxic proteins in Alzheimer's patients